Antimetastatic Activity of a Preventive Cancer Vaccine

Antimetastatic activity of a preventive cancer vaccine.

The development of prophylactic cancer vaccines that protect healthy hosts from tumor development leaves open the question whether such vaccines are also effective against established tumors and metastases. We tested the therapeutic activity of a proven prophylactic anti-HER-2/neu vaccine against successive stages of mammary carcinoma progression in HER-2/neu transgenic mice. The vaccine consis...

Antitumor and Antimetastatic Activity of

Antitumor and antimetastatic activity of IL-23.

The structure and T cell stimulatory effects of the recently discovered cytokine IL-23 are similar to, but distinct from, those of IL-12. Although the antitumor activities of IL-12 are well characterized, the effect of IL-23 on tumor growth is not known. In this study, murine CT26 colon adenocarcinoma and B16F1 melanoma cells were engineered using retroviral vectors to release single-chain IL-2...

Pneumococcal vaccine: a preventive care winner.

guidelines from the US Preventive Services Task Force.JAMA 1993;269:2678. 8. Glotzer DE, Bauchner H, Freedberg KA, Palfrey S. Screening for childhood lead poisoning: a cost-minimization analysis. Am J Public Health 1994;84: 110-2. 9. Harvey B. Should blood lead screening recommendations be revised? Pediatrics 1994;93:201-4. 10. Pirkle ]L, Brody D], Gunter EW, Kramer RA, Paschal DC, Flegal KM, e...

Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.

Matrix metalloproteinases (MMPs), and in particular gelatinases (MMP-2 and MMP-9), play a key role in cancer progression. However, clinical trials in which MMP inhibitors were tested in cancer patients have been disappointing. Whereas many reasons have been postulated to explain the failure of the clinical trials, lack of inhibitor selectivity was a major limitation. Thus, despite the consensus...